BDBM509282 US11072611, Compound 25

SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(CC(=O)N2CCC(O)C2)CC1

InChI Key InChIKey=PDLRHBOQFRLFIO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 509282   

TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM509282(US11072611, Compound 25)
Affinity DataIC50: 300nMAssay Description:TABLE V: 5 μL of a dilution series of compound, starting from 20 μM highest concentration, 1/5 dilution, is added to the wells. hENPP2 is u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
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TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM509282(US11072611, Compound 25)
Affinity DataIC50: 50nMAssay Description:TABLE VI: (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotaxin substrate FS-3 as substrate. FS-3 is a doubly l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
Go to US Patent