BDBM508551 8-{2-[(3S,4S)-3,4- difluoropyrrolidin-1-yl]ethyl}- 2,2-difluoro[1,3]dioxolo[4,5- h][1,2,4]triazolo[1,5- c]quinazolin-5-amine::US11046714, Example 23

SMILES Nc1nc2c3OC(F)(F)Oc3ccc2c2nc(CCN3C[C@H](F)[C@@H](F)C3)nn12

InChI Key InChIKey=NXPBMMZAICGBLE-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 508551   

TargetAdenosine receptor A2a(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM508551(8-{2-[(3S,4S)-3,4- difluoropyrrolidin-1-yl]ethyl}-...)
Affinity DataKi:  1.60nMAssay Description:The following table shows representative data for the compounds of the Examples as A2a receptor antagonists as determined by a competition binding as...More data for this Ligand-Target Pair
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Date in BDB:
12/28/2021
Entry Details
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