BDBM508536 2,2-difluoro-8-[2-(2-methyl-6,7- dihydro[1,3]thiazolo[4,5- c]pyridin-5(4H)-yl)ethyl][1,3] dioxolo[4,5-h][1,2,4]triazolo [1,5-c]quinazolin-5-amine::US11046714, Example 13

SMILES Cc1nc2CN(CCc3nc4c5ccc6OC(F)(F)Oc6c5nc(N)n4n3)CCc2s1

InChI Key InChIKey=VSADVRQGSKOOFG-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 508536   

TargetAdenosine receptor A2a(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM508536(2,2-difluoro-8-[2-(2-methyl-6,7- dihydro[1,3]thiaz...)
Affinity DataKi:  1.80nMAssay Description:The following table shows representative data for the compounds of the Examples as A2a receptor antagonists as determined by a competition binding as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2021
Entry Details
Go to US Patent