BDBM507742 1-(7-chloro-1-(3-fluorophenyl)-2-oxo- 1,2-dihydroquinazolin-4-yl)azetidine-3- carbonitrile::US11046691, Compound 82::US11084798, Cpd No 82::US11130759, Cpd. No. 82

SMILES Fc1cccc(c1)-n1c2cc(Cl)ccc2c(nc1=O)N1CC(C1)C#N

InChI Key InChIKey=KDUZUFWUAWCHLM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 507742   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507742(US11130759, Cpd. No. 82 | US11046691, Compound 82 ...)
Affinity DataIC50: 200nMAssay Description:Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507742(US11130759, Cpd. No. 82 | US11046691, Compound 82 ...)
Affinity DataIC50: 200nMAssay Description:5 μL of 3× final concentration test compounds in DMSO or DMSO were transferred to the appropriate wells of a microtiter plate and the plate was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507742(US11130759, Cpd. No. 82 | US11046691, Compound 82 ...)
Affinity DataIC50: 200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent