BDBM50668416 CHEMBL6191989
SMILES CCOC(=O)c1c(C2CN(c3cc(C(=O)NCCN(CC)CC)c4ccccc4n3)C2)nc2ccccn12
InChI Key InChIKey=QIJKBARUWZJMRG-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50668416
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of PDE10A (449 to 770 residues) (unknown origin) extracted from Escherichia coli BL21 using 3H-cAMP as substrate incubated for 15 mins by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of PDE4D (86 to 413 residues) (unknown origin) using 3H-cAMP as substrate incubated for 15 mins by liquid scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE5A1 (535 to 860 residues) (unknown origin) extracted from Escherichia coli BL21 using 3H-cGMP as substrate incubated for 15 mins by ...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE6C (1 to 858 residues) (unknown origin) using 3H-cGMP as substrate incubated for 15 mins by liquid scintillation counter analysisMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE7A1 (130 to 482 residues) (unknown origin) using 3H-cAMP as substrate incubated for 15 mins by liquid scintillation counter analysisMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE1C (147 to 531 residues) (unknown origin) using 3H-cGMP/3H-cAMP as substrate incubated for 15 mins by liquid scintillation counter a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) using 3H-cGMP as substrate incubated for 15 mins by liquid scintillation counter analysisMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) using 3H-cAMP as substrate incubated for 15 mins by liquid scintillation counter analysisMore data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant PDE9A2 (181 to 506 residues) (unknown origin) extracted from Escherichia coli BL21 using 3H-cGMP as substrate incubated for...More data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Sun Yat-sen University
Curated by ChEMBL
Sun Yat-sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE11A4 (588 to 911 residues) (unknown origin) using 3H-cGMP/3H-cAMP as substrate incubated for 15 mins by liquid scintillation counter...More data for this Ligand-Target Pair