BDBM50667953 CHEMBL6190817

SMILES CNC(=O)C(C)n1cc(Nc2nc(N[C@@H](C)C3CC3)c3cc[nH]c3n2)nn1

InChI Key InChIKey=JGYZMFJXIWIGGZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50667953   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Duke University School of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667953BDBM50667953(CHEMBL6190817)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant wild type GST-LRRK2 (unknown origin) purified from baculovirus infected Sf9 cells assessed as autophosphorylation using RLG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Duke University School of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667953BDBM50667953(CHEMBL6190817)
Affinity DataIC50: 32nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin) purified from baculovirus infected Sf9 cells assessed as autophosphorylation using RLGAWRFYTLRRARQ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Duke University School of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667953BDBM50667953(CHEMBL6190817)
Affinity DataIC50: 49nMAssay Description:Inhibition of LRRK2 activity in human A549 cells assessed as reduction in pRAB10 level measured after 2 hrs by immunoblot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed