BDBM50667438 CHEMBL6192917

SMILES Cc1c(cccc1C(F)(F)F)[C@@H](C)NC2=NC3=C(CNCC3)C4=CC(=O)N(C=C42)C5CCOCC5

InChI Key InChIKey=ALSMRGTYWDRDTI-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50667438   

TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667438BDBM50667438(CHEMBL6192917)
Affinity DataIC50: 3.40nMAssay Description:Binding affinity to recombinant human His10-tagged SOS1 (564 to 1049 residues) assessed as inhibition of GST-tagged human KRAS G12C mutant (1 to 169 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667438BDBM50667438(CHEMBL6192917)
Affinity DataIC50: 31nMAssay Description:Inhibition of SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in ERK phosphorylation measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)