BDBM50667153 CHEMBL6168556

SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NCC(F)(F)C(O)C1CC(F)(F)C1

InChI Key InChIKey=INFXTIWUPWDDQY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50667153   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667153BDBM50667153(CHEMBL6168556)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667153BDBM50667153(CHEMBL6168556)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50667153BDBM50667153(CHEMBL6168556)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed