BDBM50667148 CHEMBL6163751

SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NC(CF)CC(O)c1ccc(Cl)cc1

InChI Key InChIKey=ASFRLTODYTWPAU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50667148   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667148BDBM50667148(CHEMBL6163751)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667148BDBM50667148(CHEMBL6163751)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50667148BDBM50667148(CHEMBL6163751)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed