BDBM50666975 CHEMBL6169507

SMILES c1cc(cc(c1)Cl)C(COc2cnc(cn2)C(=O)NC3(CC3)c4cnccn4)(F)F

InChI Key InChIKey=QMNWVTZDJYYZOV-UHFFFAOYSA-N

Data  1 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50666975   

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 42nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 79nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A/GluN2B expressed Xenopus oocytes measured after 2 to 6 days by two-electrode voltage clamp recor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataKi:  183nMAssay Description:Displacement of [3H]-1 from full length rat hippocampal membrane GluN1/GluN2A assessed as inhibition constant by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 1.30E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2B expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2D expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
Janssen Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666975BDBM50666975(CHEMBL6169507)
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human GluN1/GluN2C expressed in T-REx-CHO-K1 cells by fluorometric calcium mobilization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)