BDBM50666719 CHEMBL6177729

SMILES CN1CCC[C@@H](Nc2nnc(-c3ccc(C(F)(F)F)cc3O)c3c2CCCC3)C1

InChI Key InChIKey=YVCOPUPWDKEPBL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50666719   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
A Johnson & Johnson Company

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666719BDBM50666719(CHEMBL6177729)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of NLRP3 in LPS-induced human PBMC cells assessed as inhibition of IL-1beta secretion pretreated with compound for 30 mins followed by LPS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
A Johnson & Johnson Company

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666719BDBM50666719(CHEMBL6177729)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NLRP3 in LPS-induced human PBMC cells assessed as inhibition of TNF-alpha secretion pretreated with compound for 30 mins followed by LP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
A Johnson & Johnson Company

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666719BDBM50666719(CHEMBL6177729)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NLRP3 in LPS-induced human PBMC cells assessed as inhibition of IL-6 secretion pretreated with compound for 30 mins followed by LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed