BDBM506659 4-chloro-N-((R)-cyclo- propyl((1R,3s,5S,6r)-3- (5,6-difluoro-1H-benzo[d]- imidazol-1-yl)- bicyclo[3.1.0]hexan-6- yl)methyl)benzamide::US11046649, Ex. 37

SMILES Fc1cc2ncn([C@H]3C[C@H]4[C@@H](C3)[C@@H]4[C@H](NC(=O)c3ccc(Cl)cc3)C3CC3)c2cc1F

InChI Key InChIKey=APCGWDFDSUEECQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 506659   

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Of Texas

US Patent
LigandPNGBDBM506659(US11046649, Ex. 37 | 4-chloro-N-((R)-cyclo- propyl...)
Affinity DataIC50: 3.60nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Of Texas

US Patent
LigandPNGBDBM506659(US11046649, Ex. 37 | 4-chloro-N-((R)-cyclo- propyl...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM506659(US11046649, Ex. 37 | 4-chloro-N-((R)-cyclo- propyl...)
Affinity DataIC50: 560nMAssay Description:Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed