BDBM50665647 CHEMBL6171702

SMILES C[C@H]1CCCCN1C(=O)c1nc(C(=O)NCC(C)(C)O)sc1-c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1Cl

InChI Key InChIKey=NRFPNWGRYUYKLF-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50665647   

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665647BDBM50665647(CHEMBL6171702)
Affinity DataKd:  0.0580nMAssay Description:Inverse agonist activity at N-terminal his-tagged wild type human RORgammat LBD domain expressed in Escherichia coli assessed as dissociation constan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665647BDBM50665647(CHEMBL6171702)
Affinity DataIC50: 81nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as IL-17A production incubated for 1 hrs by ELISA analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNuclear receptor ROR-beta(Human)
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665647BDBM50665647(CHEMBL6171702)
Affinity DataKd:  430nMAssay Description:Inverse agonist activity at human RORbeta assessed as dissociation constant by thermofluor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed