BDBM50665242 CHEMBL6177653

SMILES NC1CCN(C(=O)c2cc(S(=O)(=O)Nc3nc4c(O)ccc(Cl)c4s3)ccc2O)CC1

InChI Key InChIKey=LLHASKAXGJQRCZ-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50665242   

TargetGTPase KRas(Human)
CRUK Scotland Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665242BDBM50665242(CHEMBL6177653)
Affinity DataKd: <2.00E+3nMAssay Description:Binding affinity to GDP bound KRas G12D mutant (unknown origin) assessed as dissociation constant by 1H NMR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
CRUK Scotland Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665242BDBM50665242(CHEMBL6177653)
Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of MANT-GDP loaded Kras G12D mutant (1 to 169 residues) (unknown origin)/SOS1 (546 to 1049 residues) (unknown origin) protein-protein inte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
CRUK Scotland Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665242BDBM50665242(CHEMBL6177653)
Affinity DataKd:  1.80E+5nMAssay Description:Binding affinity to GMPPNP-bound KRas G12D mutant (unknown origin) assessed as dissociation constant by 1H NMR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed