BDBM506627 US11046649, Ex. 5

SMILES Fc1cc2ncn([C@@H]3C[C@H]4[C@H](CNC(c5ccc(Cl)cc5)C(F)(F)F)[C@H]4C3)c2cc1F

InChI Key InChIKey=YRBZTSFREOOWCL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 506627   

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Of Texas

US Patent
LigandPNGBDBM506627(US11046649, Ex. 5)
Affinity DataIC50: 472nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Of Texas

US Patent
LigandPNGBDBM506627(US11046649, Ex. 5)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM506627(US11046649, Ex. 5)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using sulfaphenazole as substrate incubated for 10 mins in presence of NADPH by LCMS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM506627(US11046649, Ex. 5)
Affinity DataIC50: 460nMAssay Description:Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed