BDBM50662573 CHEMBL6171925

SMILES CC(C)(O)c1csc(S(=O)(=O)NC(=O)Nc2c(-c3cccc(Cl)c3Cl)ccc3c2CCC3)c1

InChI Key InChIKey=SZXAJFHUVSPWPP-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50662573   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Peking University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662573BDBM50662573(CHEMBL6171925)
Affinity DataKd:  6.90nMAssay Description:Binding affinity to NLRP3 NACHT domain (unknown origin) expressed in Sf9 insect cells assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Peking University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662573BDBM50662573(CHEMBL6171925)
Affinity DataIC50: 8nMAssay Description:Inhibition of NLRP3 inflammasome pathway in human THP-1 cells assessed as LPS-stimulated IL-1beta release pretreated with LPS for 3 hrs followed by c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed