BDBM50655373 CHEMBL6103423

SMILES CCc1nc(COC)c(-c2cc3c(=O)n(C)cc(-c4cc(C(C)(C)O)ccc4Oc4c(C)cc(F)cc4C)c3o2)[nH]1

InChI Key InChIKey=FGMZZPSGWQQHGY-UHFFFAOYSA-N

Data  5 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50655373   

TargetBromodomain-containing protein 4(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655373BDBM50655373(CHEMBL6103423)
Affinity DataKd: <1nMAssay Description:Binding affinity to N-terminal his 6 tagged human BRD4 BD2 (348 to 464 residues) extracted from Escherichia coli BL21 (DE3) cells assessed as dissoci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655373BDBM50655373(CHEMBL6103423)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of N-terminal GST fused his tagged human BRD4 BD2 (348 to 464 residues) extracted from Escherichia coli BL21 (DE3) cells using biotinylate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655373BDBM50655373(CHEMBL6103423)
Affinity DataIC50: 53nMAssay Description:Inhibition of N-terminal GST fused his tagged human BRD2 BD2 (347 to 455 residues) extracted from Escherichia coli BL21 (DE3) cells using biotinylate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655373BDBM50655373(CHEMBL6103423)
Affinity DataKd:  66nMAssay Description:Binding affinity to N-terminal GST fused his 6 tagged human BRD2 BD2 (347 to 455 residues) extracted from Escherichia coli BL21 (DE3) cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655373BDBM50655373(CHEMBL6103423)
Affinity DataIC50: 71nMAssay Description:Inhibition of N-terminal GST fused his tagged human BRD3 BD2 (307 to 419 residues) extracted from Escherichia coli BL21 (DE3) cells using biotinylate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655373BDBM50655373(CHEMBL6103423)
Affinity DataKd:  83nMAssay Description:Binding affinity to N-terminal GST fused his 6 tagged human BRD3 BD2 (307 to 419 residues) extracted from Escherichia coli BL21 (DE3) cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655373BDBM50655373(CHEMBL6103423)
Affinity DataKd:  142nMAssay Description:Binding affinity to N-terminal GST fused his 6 tagged human BRDT BD2 extracted from Escherichia coli BL21 (DE3) cells assessed as dissociation consta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655373BDBM50655373(CHEMBL6103423)
Affinity DataIC50: 183nMAssay Description:Inhibition of N-terminal GST fused his tagged human BRDT BD2 extracted from Escherichia coli BL21 (DE3) cells using biotinylated tetraacetylated Hist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50655373BDBM50655373(CHEMBL6103423)
Affinity DataIC50: 3.87E+3nMAssay Description:Inhibition of PI3Kalpha in human T47D cells by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed