BDBM50653010 CHEMBL5712062

SMILES C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)C2C=CC(F)=CC21

InChI Key InChIKey=VXYZCOCRVAQWBG-UHFFFAOYSA-N

Data  5 KI  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50653010   

TargetBDNF/NT-3 growth factors receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 23nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 0.230nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 529nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 319nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 56nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase FRK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 53nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 46nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 24nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Fes/Fps(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Fer(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 3.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 2.70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataKi: <0.0250nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataKi: <0.0700nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed