BDBM50652900 CHEMBL4746525

SMILES C[C@H]1CC(=O)Nc2cc(C(=O)NCCC3CC3)ccc2N1C(=O)N1CC2CC2C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50652900   

TargetRibosomal protein S6 kinase alpha-6(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of RSK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDGFR beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of p38alpha (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of NUAK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of TBK1 (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of Tak1 (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of Tak1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of human TRK-AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged ERK5 catalytic domain (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of human PIP4K2AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of human DYRK1aMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of GSK-3-beta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of MEK5 (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of MAP4K1 (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of KDR (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 (unknown origin) in BGG-buffer in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDiacylglycerol kinase alpha(Mus musculus)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse DGK alpha by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of MST1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of MKNK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of MKNK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK12 (unknown origin) by using c-myc peptide as substrate in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of Bub1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of Aurora A (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCasein kinase I isoform gamma-3(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of CSNK1G3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCasein kinase I isoform alpha(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of CSNK1A1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2/CyclinE (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 13(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK13 (unknown origin) by using c-myc peptide as substrate in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFYN-binding protein 1(Homo sapiens)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of T-Fyn (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 8.80nMAssay Description:Binding affinity to recombinant human SMYD3 expressed in Escherichia coli assessed as catalytic inhibition using DYDNPIFEKFGKGGTYPRRYHVSYHGK-Biotin a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataKd:  97nMAssay Description:Binding affinity to biotinylated SMYD3 (unknown origin) assessed as dissociation constant using S-adenosyl-l-methionine as substrate by surface plasm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataKd:  133nMAssay Description:Binding affinity to recombinant human SMYD3 expressed in Escherichia coli assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 183nMAssay Description:Inhibition of SMYD3 catalytic inactive mutant co-expressed with HA-tagged MAP3K2 transfected in human HeLa cells assessed as reduction of MAP3K2-K260...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed