BDBM50651397 CHEMBL5632238

SMILES Cn1cccc1-c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1-c1cccc(CO)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50651397   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651397(CHEMBL5632238)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK2 (8 to 310 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651397(CHEMBL5632238)
Affinity DataIC50: 95nMAssay Description:Inhibition of RIPK2-mediated NF-kappaB signalling in MDP-treated human THP-1 cells preincubated for 30 mins followed by MDP addition measured after 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651397(CHEMBL5632238)
Affinity DataIC50: 119nMAssay Description:Inhibition of RIPK2-mediated NF-kappaB signalling in C14-TriLAN-Gly-treated human THP-1 cells preincubated for 30 mins followed by C14-TriLAN-Gly add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651397(CHEMBL5632238)
Affinity DataIC50: 141nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK3 (1 to 307 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 4(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651397(CHEMBL5632238)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK4 (1 to 321 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651397(CHEMBL5632238)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK1 (1 to 321 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed