BDBM50651396 CHEMBL5631246

SMILES OCc1cccc(-c2cc3ncnc(Nc4ccc5scnc5c4)c3cc2-c2cccs2)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50651396   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651396(CHEMBL5631246)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK2 (8 to 310 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651396(CHEMBL5631246)
Affinity DataIC50: 396nMAssay Description:Inhibition of RIPK2-mediated NF-kappaB signalling in MDP-treated human THP-1 cells preincubated for 30 mins followed by MDP addition measured after 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651396(CHEMBL5631246)
Affinity DataIC50: 432nMAssay Description:Inhibition of RIPK2-mediated NF-kappaB signalling in C14-TriLAN-Gly-treated human THP-1 cells preincubated for 30 mins followed by C14-TriLAN-Gly add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651396(CHEMBL5631246)
Affinity DataIC50: 551nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK3 (1 to 307 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 4(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651396(CHEMBL5631246)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK4 (1 to 321 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50651396(CHEMBL5631246)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal polyHis-tagged human RIPK1 (1 to 321 residues) expressed in Sf9 cells using MBP as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed