BDBM50641291 CHEMBL5566020

SMILES CN1CCN(Cc2ccc(NC(=O)c3cncc(C#Cc4cnc(N)nc4)c3)cc2C(F)(F)F)CC1

InChI Key InChIKey=WXTPIRWETKOHAO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50641291   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 3.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 3.90nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 8.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641291(CHEMBL5566020)
Affinity DataIC50: 47nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed