BDBM50634625 CHEMBL5408807::US20240300923, Example 22

SMILES COc1cc2nn(cc2cc1C(=O)Nc1cccn(C)c1=O)[C@H]1CC[C@@H](CC1)n1ccccc1=O

InChI Key InChIKey=PGQKQMFRLFTWHA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50634625   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

US Patent
LigandPNGBDBM50634625(US20240300923, Example 22 | CHEMBL5408807)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Astrazeneca

US Patent
LigandPNGBDBM50634625(US20240300923, Example 22 | CHEMBL5408807)
Affinity DataIC50: 2.62E+4nMAssay Description:Potency of IRAK4 Inhibitor Compounds in cKit Enzyme Assay. Evaluation of the effects of the IRAK4 inhibitor compounds on the activity of the human cK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

US Patent
LigandPNGBDBM50634625(US20240300923, Example 22 | CHEMBL5408807)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human full length his-tagged IRAK4 expressed in insect cells using KKARFSRFAGSSPSQSSMVAR as peptide substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2024
Entry Details
PubMed