BDBM50634623 CHEMBL5410702::US20240300923, Example 14

SMILES COc1cc2nn(cc2cc1C(=O)Nc1cccn(-c2cn[nH]c2)c1=O)[C@H]1CC[C@@H](CC1)N(C)C(=O)[C@@H](C)O

InChI Key InChIKey=PLJKLBZJIZNCRS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634623   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

US Patent
LigandPNGBDBM50634623(US20240300923, Example 14 | CHEMBL5410702)
Affinity DataIC50: 0.300nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

US Patent
LigandPNGBDBM50634623(US20240300923, Example 14 | CHEMBL5410702)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human full length his-tagged IRAK4 expressed in insect cells using KKARFSRFAGSSPSQSSMVAR as peptide substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2024
Entry Details
PubMed