BDBM50634591 CHEMBL5436458

SMILES CC1(N)CCN(CC1)c1ccnc2c(Sc3cccc(Cl)c3Cl)cnn12

InChI Key InChIKey=HISMEBLGFATKPW-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634591   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50634591(CHEMBL5436458)Copy SMILESCopy InChI

Affinity DataIC50: 530nMAssay Description:Allosteric inhibition of recombinant full length 6His-tagged SHP2 (2 to 527 residues) (unknown origin) expressed in Escherichia coli using DiFMUP as ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/22/2024
Entry Details
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TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Pfizer

Curated by ChEMBL

LigandBDBM50634591(CHEMBL5436458)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human KYSE520 cells incubated for 1 hrs by Western blot analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/22/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL