BDBM50634563 CHEMBL5434221

SMILES C[C@H]1CN(CCO1)Cc2ccccc2C(=O)N[C@@H]3C(=O)Nc4cnccc4C(=N3)c5ccccc5

InChI Key InChIKey=JNGHRJXDWKEWQM-UHFFFAOYSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50634563   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634563(CHEMBL5434221)
Affinity DataIC50: 3.72E+4nMAssay Description:Inhibition of recombinant Cbl-b (unknown origin) mediated ZAP70 ubiquitination incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634563(CHEMBL5434221)
Affinity DataIC50: 15nMAssay Description:Displacement of FAM-labeled probe from recombinant biotinylated Cbl-b (unknown origin) expressed in Escherichia coli BL21(DE3) Tuner cells by TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634563(CHEMBL5434221)
Affinity DataEC50:  410nMAssay Description:Inhibition of Cbl-b in cryo-preserved human CD3-positive T cells assessed as increase in IL-2 production preincubated for 1 hr followed by alpha-CD3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634563(CHEMBL5434221)
Affinity DataIC50: 5.05E+4nMAssay Description:Inhibition of recombinant Cbl-b (unknown origin) ubiquitination incubated for 60 mins in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)