BDBM50634559 CHEMBL5420341::US20250171467, Compound 20

SMILES COc1ccc(cc1C)-n1nc(C(=O)N2CCN3CCC2CC3)c2CCCc12

InChI Key InChIKey=OLBSZULQEKARAI-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634559   

TargetCeramide glucosyltransferase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50634559(CHEMBL5420341 | US20250171467, Compound 20)
Affinity DataEC50:  0.400nMAssay Description:Inhibition of GCS activity in human A-375 cells using C6 ceramide as substrate pre-incubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetUDP-glucose 6-dehydrogenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50634559(CHEMBL5420341 | US20250171467, Compound 20)
Affinity DataEC50:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2025
Entry Details
Go to US Patent