BDBM50634535 CHEMBL5434895

SMILES ONC(=O)CCCCCCNC(=O)c1ccc(NC(=O)CNC(=O)CC2c3ccccc3-c3ccccc23)cc1

InChI Key InChIKey=RDHSLZUUTQWAGA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50634535   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50634535(CHEMBL5434895)
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant HDAC in human MM.1S cells using Boc-Lys(Epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50634535(CHEMBL5434895)
Affinity DataIC50: 86nMAssay Description:Inhibition of C-terminal 6His tagged human recombinant full length HDAC1 (1 to 482 residues) using Z- Lys(Ac)-AMC as fluorogenic substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50634535(CHEMBL5434895)
Affinity DataIC50: 157nMAssay Description:Inhibition of C-terminal flag tagged human recombinant full length HDAC2 (1 to 488 residues) using Z- Lys(Ac)-AMC as fluorogenic substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50634535(CHEMBL5434895)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of C-terminal GST tagged human recombinant full length HDAC6 (1 to 1215 residues) using Z- Lys(Ac)-AMC as fluorogenic substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed