BDBM50634224 CHEMBL5422375

SMILES C[C@@]1(O)C[C@@H](C1)Nc1nnc(c2COCc12)-c1ccc(cc1O)C(F)(F)F

InChI Key InChIKey=DJFUDVJAHFSOIL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50634224   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50634224(CHEMBL5422375)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of NLRP3 in human PBMC cells assessed as reduction in Il-1beta production preincubated for 0.5 hrs followed by LPS treatment for 3.5 hrs a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50634224(CHEMBL5422375)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta production preincubated for 1 hrs followed by nigericin addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed