BDBM50634053 CHEMBL5432407

SMILES CCN(CC)C(=O)c1cc(nc2n(nc(C(F)F)c12)-c1ccccc1)-c1ccnn1C

InChI Key InChIKey=YFJNYMCLZGUFEA-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50634053   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Montclair State University

Curated by ChEMBL
LigandPNGBDBM50634053(CHEMBL5432407)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant PDE11A4 (1 to 943 residues) expressed in Sf9 insect cells using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Montclair State University

Curated by ChEMBL
LigandPNGBDBM50634053(CHEMBL5432407)
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant PDE11A4 (1 to 943 residues) expressed in Sf9 insect cells using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Mus musculus)
Montclair State University

Curated by ChEMBL
LigandPNGBDBM50634053(CHEMBL5432407)
Affinity DataEC50:  2.50E+3nMAssay Description:Inhibition of PDE11A4 in mouse HT-22 cells assessed as reduction in cAMP hydrolytic activity using [3H]-cAMP as substrate pretreated with compound fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Mus musculus)
Montclair State University

Curated by ChEMBL
LigandPNGBDBM50634053(CHEMBL5432407)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of PDE11A4 in mouse HT-22 cells assessed as reduction in cGMP hydrolytic activity using [3H]-cGMP as substrate pretreated with compound fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Montclair State University

Curated by ChEMBL
LigandPNGBDBM50634053(CHEMBL5432407)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed