BDBM50632831 CHEMBL5406943

SMILES CCc1cc2n(CCOCC(C)C)c3nc(=O)[nH]c(=O)c3nc2cc1Cl

InChI Key InChIKey=IOHJEWFKBRNJIO-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50632831   

TargetHistone acetyltransferase type B catalytic subunit(Homo sapiens)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50632831(CHEMBL5406943)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of C-terminal FLAG tagged full length human HAT1/Rbap46 transfected in HEK293F cells using histone H4 peptide as substrate and 4-pentynoyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase type B catalytic subunit(Homo sapiens)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50632831(CHEMBL5406943)
Affinity DataKd:  5.20E+3nMAssay Description:Binding affinity to CM5 sensor chip immobilized C-terminal FLAG tagged full length human HAT1/Rbap46 assessed as dissociation constant by SPR analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50632831(CHEMBL5406943)
Affinity DataIC50: 9.04E+4nMAssay Description:Inhibition of human CBP incubated for 20 mins followed by 3H-Acetyl CoA addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT5(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50632831(CHEMBL5406943)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human KAT5 incubated for 20 mins followed by 3H-Acetyl CoA addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT7(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50632831(CHEMBL5406943)
Affinity DataIC50: 8.48E+4nMAssay Description:Inhibition of human MYST2 incubated for 20 mins followed by 3H-Acetyl CoA addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT6B(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50632831(CHEMBL5406943)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human MYST4 incubated for 20 mins followed by 3H-Acetyl CoA addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50632831(CHEMBL5406943)
Affinity DataIC50: 7.43E+4nMAssay Description:Inhibition of human p300 incubated for 20 mins followed by 3H-Acetyl CoA addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase type B catalytic subunit(Homo sapiens)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50632831(CHEMBL5406943)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of C-terminal FLAG tagged full length human HAT1/Rbap46 transfected in HEK293F cells using histone H4 peptide as substrate and acetyl-CoA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed