BDBM50632230 CHEMBL5435463

SMILES OCCNc1ncnc2oc(c(-c3cccc(NC(=O)C=C)c3)c12)-c1ccc(cc1)N1CCOCC1

InChI Key InChIKey=UXMLKDZZKQIMQH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50632230   

TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50632230(CHEMBL5435463)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged recombinant EGFR (G696 to G1022 residues) L858R/T790M double mutant (unknown origin) using poly(Glu, Tyr) 4:1 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50632230(CHEMBL5435463)
Affinity DataIC50: 43nMAssay Description:Inhibition of GST-tagged recombinant wild type EGFR (G696 to G1022 residues) (unknown origin) using poly(Glu, Tyr) 4:1 as substrate incubated for 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed