BDBM50632089 CHEMBL5307400

SMILES CCn1c(=O)c(C)cn(Cc2nnc(s2)-c2ccc(F)c(O)c2F)c1=O

InChI Key InChIKey=XKDHFIPNTTUSIA-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50632089   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50632089(CHEMBL5307400)
Affinity DataIC50: 1nMAssay Description:Uncompetitive inhibition of recombinant human full-length C-terminal His-tagged HSD17B13 using estradiol and NAD as substrate preincubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetEstradiol 17-beta-dehydrogenase 11(Homo sapiens)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50632089(CHEMBL5307400)
Affinity DataIC50: 1.00E+4nMAssay Description:Uncompetitive inhibition of recombinant human full-length C-terminal His-tagged HSD17B11 using estradiol and NAD as substrate preincubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50632089(CHEMBL5307400)
Affinity DataIC50: 11nMAssay Description:Uncompetitive inhibition of recombinant human full-length C-terminal His-tagged HSD17B13 expressed in HEK293 cells using estradiol as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
Target17-beta-hydroxysteroid dehydrogenase 13(Mus musculus)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50632089(CHEMBL5307400)
Affinity DataIC50: 14nMAssay Description:Uncompetitive inhibition of recombinant mouse full-length C-terminal His-tagged HSD17B13 using estradiol and NAD as substrate preincubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
Target17-beta-hydroxysteroid dehydrogenase 13(Mus musculus)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50632089(CHEMBL5307400)
Affinity DataKi:  0.5nMAssay Description:Tight binding inhibition of recombinant mouse full-length C-terminal His-tagged HSD17B13 assessed as inhibition constant by morrison equationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
Target17-beta-hydroxysteroid dehydrogenase 13(Mus musculus)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50632089(CHEMBL5307400)
Affinity DataKi:  0.5nMAssay Description:Uncompetitive tight binding inhibition of recombinant mouse full-length C-terminal His-tagged HSD17B13 assessed as inhibition constant in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50632089(CHEMBL5307400)
Affinity DataKi:  0.700nMAssay Description:Tight binding inhibition of recombinant human full-length C-terminal His-tagged HSD17B13 assessed as inhibition constant by morrison equationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50632089(CHEMBL5307400)
Affinity DataKi:  0.700nMAssay Description:Uncompetitive tight binding inhibition of recombinant human full-length C-terminal His-tagged HSD17B13 assessed as inhibition constant in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed