BDBM50631650 CHEMBL5396153

SMILES FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2sccc2c1

InChI Key InChIKey=RPVUYLFRBVBINJ-UHFFFAOYSA-N

Data  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50631650   

TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50631650(CHEMBL5396153)
Affinity DataEC50:  120nMAssay Description:Positive allosteric modulation of C-terminal His6-tagged wild type human NAMPT using NAM and PRPP as substrates measured for 1 hr by NMNAT1-coupled e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50631650(CHEMBL5396153)
Affinity DataKd:  477nMAssay Description:Displacement of FP-probe ZN-2-102 from C-terminal His6-tagged wild type human NAMPT rear channel assessed as dissociation constant by fluorescence po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50631650(CHEMBL5396153)
Affinity DataEC50:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed