BDBM50631475 CHEMBL5436246::US20250073340, Example 1

SMILES COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc23)[C@H]1c1cccc(Cl)c1F)C(N)=O

InChI Key InChIKey=OEKPQJDPZAKXBX-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50631475   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM50631475(CHEMBL5436246 | US20250073340, Example 1)
Affinity DataIC50: 0.370nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM50631475(CHEMBL5436246 | US20250073340, Example 1)
Affinity DataKi:  2.30nMAssay Description:Inhibition of MDM2 (1 to 118 residues)/p53 (unknown origin) interaction expressed in Escherichia coli BL21(DE3) cells assessed as inhibition constant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetProtein Mdm4(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50631475(CHEMBL5436246 | US20250073340, Example 1)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of MDM4 (14 to 111 residues)/p53 (unknown origin) interaction expressed in Escherichia coli BL21(DE3) cells assessed as inhibition constan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed