BDBM50631201 CHEMBL5435568

SMILES N[C@H](CO)Cn1ccc(n1)-c1ccc(Oc2ncc(cc2F)-c2cc[nH]n2)cc1

InChI Key InChIKey=NQHGXSVGARINPB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50631201   

TargetLeukotriene A-4 hydrolase(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50631201(CHEMBL5435568)
Affinity DataIC50: 3nMAssay Description:Inhibition of LTA4H (unknown origin) using Arg-AMC as substrate preincubated with compound for 15 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50631201(CHEMBL5435568)
Affinity DataIC50: 47nMAssay Description:Inhibition of LTA4H in human whole blood assessed as ionophore-stimulated LTB4 release preincubated for 15 mins by competitive immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50631201(CHEMBL5435568)
Affinity DataIC50: 47nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50631201(CHEMBL5435568)
Affinity DataIC50: 47nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed