BDBM50631109 CHEMBL5398202

SMILES N[C@H]1CN(CC[C@H]1F)c1ncnc2[nH]c(Cl)c(-c3cccc(c3)C#N)c12

InChI Key InChIKey=PPGUULSJUXLSJS-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50631109   

LigandPNGBDBM50631109(CHEMBL5398202)
Affinity DataIC50: 154nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation pretreated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50631109(CHEMBL5398202)
Affinity DataIC50: 36nMAssay Description:Inhibition of MAP4K3 (unknown origin) by by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50631109(CHEMBL5398202)
Affinity DataIC50: 154nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP-76 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631109(CHEMBL5398202)
Affinity DataIC50: 154nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50631109(CHEMBL5398202)
Affinity DataKi:  1.70nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50631109(CHEMBL5398202)
Affinity DataKi:  1.80nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631109(CHEMBL5398202)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed