BDBM50631101 CHEMBL5435769

SMILES CC1(C)NC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccc(F)cc4)n3)cc12

InChI Key InChIKey=RWTXXGPUNDKBLW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50631101   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50631101(CHEMBL5435769)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues) expressed in baculovirus-infected Sf9 cells using myelin basic protein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50631101(CHEMBL5435769)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues) expressed in baculovirus-infected Sf9 cells using myelin basic protein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50631101(CHEMBL5435769)
Affinity DataIC50: 4.96E+3nMAssay Description:Inhibition of N-terminal GST-tagged human full length recombinant GCK expressed in baculovirus-infected Sf9 cells using myelin basic protein as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50631101(CHEMBL5435769)
Affinity DataIC50: 61nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant GLK (1 to 380 residues) expressed in baculovirus-infected Sf9 cells using PKA substrate by ADP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50631101(CHEMBL5435769)
Affinity DataIC50: 246nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HGK (1 to 328 residues) expressed in bacuovirus-infected Sf9 cells using myelin basic protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50631101(CHEMBL5435769)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal GST-tagged human full length recombinant KHS expressed in baculovirus-infected Sf9 cells using myelin basic protein as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed