BDBM50630760 CHEMBL5433283

SMILES Cc1cccc2c(c[nH]c12)-c1ncc2N(C(=O)[C@]3(C)COCCN3c2n1)C1(CCCO)CC1

InChI Key InChIKey=QRKKQWDDVIUFBU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50630760   

TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50630760(CHEMBL5433283)
Affinity DataIC50: 5nMAssay Description:Inhibition of mTORC2 in human PC-3 cells assessed as AKT phosphorylation at S473 residue in incubated for 1 hr by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50630760(CHEMBL5433283)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of recombinant human GST-tagged mTOR (1360 to 2549 residues) expressed in insect cells using GFP-4E-BP1 as substrate incubated for 30 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed