BDBM50630639 CHEMBL5404510

SMILES CCN1c2c(n(c(n2)Cc3cn4cc(sc4n3)C)CC5COC5)C(=O)NC1=O

InChI Key InChIKey=FJDRFUYWOVFIPP-UHFFFAOYSA-N

Data  3 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50630639   

TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM50630639(CHEMBL5404510)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM50630639(CHEMBL5404510)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to THP1 (unknown origin) assessed as equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM50630639(CHEMBL5404510)
Affinity DataIC50: 952nMAssay Description:Inhibition of THP1 in human serotonergic BON cells assessed as reduced the intracellular serotonin levels incubated for 72 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Leibniz-Fmp

Curated by ChEMBL
LigandPNGBDBM50630639(CHEMBL5404510)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of P-gp in human Caco-2 cells seeded in polyethylene membranes assessed as permeation in presence or absence of digoxin measured for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed