BDBM50630413 CHEMBL5417105

SMILES CC(C)(C)[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)CNC(=O)CC[C@H](NS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F)C(O)=O)C(=O)N1CCC[C@H]1CC(N)=O

InChI Key InChIKey=ITXQTOBRXFVFDQ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50630413   

TargetNeutrophil collagenase(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP8 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 850nMAssay Description:Inhibition of recombinant human MMP14 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP1 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of recombinant human MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetStromelysin-1(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP3 using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP9 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCollagenase 3(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP13 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrilysin(Mus musculus)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 49nMAssay Description:Inhibition of mouse MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630413(CHEMBL5417105)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed