BDBM50630328 CHEMBL5426739

SMILES Nc1cc2cccc(F)c2c(n1)-c1c(Cl)cc2c(nc(OC[C@@]34CCCN3C[C@H](F)C4)nc2c1F)N1CC2CCC(C1)N2

InChI Key InChIKey=LYDXJKYVKDPEOE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50630328   

TargetGTPase KRas(Human)
Erasca

Curated by ChEMBL
LigandPNGBDBM50630328(CHEMBL5426739)
Affinity DataIC50: 6nMAssay Description:Inhibition of GDP-bound biotinylated-KRAS G12D mutant (1 to 169 residues) (unknown origin) assessed as suppression of SOS1-mediated nucleotide exchan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Erasca

Curated by ChEMBL
LigandPNGBDBM50630328(CHEMBL5426739)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild-type GDP-bound biotinylated-KRAS (unknown origin) assessed as suppression of SOS1-mediated nucleotide exchange by measuring reduct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetGTPase KRas(Human)
Erasca

Curated by ChEMBL
LigandPNGBDBM50630328(CHEMBL5426739)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of KRAS G12D mutant in human ASPC1 cells assessed as reduction in ERK phosphorylation measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed