BDBM50630294 CHEMBL5432828::US12110276, Compound 112

SMILES OCc1ccnc2n(nc(C3CN(C3)C(=O)C=C)c12)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=FATYKAPPXHGOKR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50630294   

TargetTranscriptional enhancer factor TEF-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-5(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 9nMAssay Description:Inhibition of His-tagged TEAD3 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged TEAD4 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 9.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 3.80nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 8.90nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 3.20nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent