BDBM50630228 CHEMBL5418687

SMILES CC(=O)Nc1cc2c(cn(C)c2cn1)-c1cccc(n1)S(=O)(=O)C1COC1

InChI Key InChIKey=QFNGKVUXNMWIGS-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50630228   

LigandPNGBDBM50630228(CHEMBL5418687)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630228(CHEMBL5418687)
Affinity DataEC50:  194nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630228(CHEMBL5418687)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed