BDBM50630038 CHEMBL5403027

SMILES CN1CCN(CC1)c1ccnc(c1)C(=O)N1CCC[C@@H](C1)C(=O)Nc1cccc(c1)-c1ccc(cc1)C(N)=O

InChI Key InChIKey=KDJWESNUVQMZGH-UHFFFAOYSA-N

Data  8 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50630038   

TargetTP53-binding protein 1(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataIC50: 470nMAssay Description:Displacement of Biotin-p53K381acK382me2 from N-terminal his6-tagged 53BP1 (1484 to 1603 residues) (unknown origin) expressed in Rosetta2 BL21 (DE3) p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTP53-binding protein 1(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataKd:  790nMAssay Description:Binding affinity to N-terminal his6-tagged 53BP1 (1484 to 1603 residues) (unknown origin) expressed in Rosetta2 BL21 (DE3) pLysS competent cells asse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTP53-binding protein 1(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataKd:  850nMAssay Description:Binding affinity to N-terminal his6-tagged 53BP1 tandem tudor domain (1484 to 1603 residues) (unknown origin) expressed in Rosetta2 BL21 (DE3) pLysS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of Biotin-p53K381acK382me2 from SETDB1 tandem tudor domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase UHRF1(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of Biotin-p53K381acK382me2 from UHRF1 tandem tudor domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetPHD finger protein 19(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of Biotin-p53K381acK382me2 from PHF19 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetChromobox protein homolog 2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of Biotin-p53K381acK382me2 from CBX2 chromodomain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetChromodomain Y-like protein 2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of Biotin-p53K381acK382me2 from CDYL2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetM-phase phosphoprotein 8(Homo sapiens)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of Biotin-p53K381acK382me2 from MPP8 chromodomain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTP53-binding protein 1(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataIC50: 8.50E+3nMAssay Description:Antagonist activity at nanoluc-tagged 53BP1 tandem tudor domain (unknown origin) transfected in HEK293T cells assessed as inhibition of 53BP1-H4 pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed