BDBM50629680 (-)-Isolaureline::CHEMBL510954

SMILES [H][C@]12Cc3cc(OC)ccc3-c3c4OCOc4cc(CCN1C)c23

InChI Key InChIKey=GXFOBPWUVXXUIF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50629680   

TargetAcetylcholinesterase(Human)
Tianjin University of Technology

Curated by ChEMBL
LigandPNGBDBM50629680((-)-Isolaureline | CHEMBL510954)
Affinity DataIC50: 2.62E+4nMAssay Description:Inhibition of AChE (unknown origin) using ATCI as substrate preincubated for 15 min followed by substrate addition measured after 40 min by Ellman's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCholinesterase(Human)
Tianjin University of Technology

Curated by ChEMBL
LigandPNGBDBM50629680((-)-Isolaureline | CHEMBL510954)
Affinity DataIC50: 3.64E+4nMAssay Description:Inhibition of BChE (unknown origin) using BTCI as substrate preincubated for 15 min followed by substrate addition measured after 40 min by Ellman's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
Tianjin University of Technology

Curated by ChEMBL
LigandPNGBDBM50629680((-)-Isolaureline | CHEMBL510954)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of amyloid beta 42 (unknown origin) aggregation incubated for 24 hrs by ThT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Electric eel)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50629680((-)-Isolaureline | CHEMBL510954)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of Electrophorus electricus AChE using ATCI as substrate pre-incubated for 10 mins followed by substrate addition measured after 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCholinesterase(Horse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50629680((-)-Isolaureline | CHEMBL510954)
Affinity DataIC50: 1.66E+4nMAssay Description:Inhibition of equine serum BuChE using BTCI as substrate pre-incubated for 10 mins followed by substrate addition measured after 5 mins by microplate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed