BDBM50629602 CHEMBL5401158

SMILES O=C(Nc1ccc(cc1)N1CCNCC1)c1n[nH]cc1Nc1cc(Oc2ccccc2)ncn1

InChI Key InChIKey=RSZBDSJQRIEBFQ-UHFFFAOYSA-N

Data  3 IC50  11 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50629602   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK and [gamma-33P]-ATP as substrate pretreated for 20 mins followed by [gamma-33P]-ATP addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataIC50: 98nMAssay Description:Inhibition of human CDK2 pretreated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins in presence of 10 uM ATP by radiomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 6(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataIC50: 122nMAssay Description:Inhibition of human CDK6 pretreated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins in presence of 10 uM ATP by radiomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  49nMAssay Description:Binding affinity to FLT3 D835H mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  22nMAssay Description:Binding affinity to FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to FLT3 D835V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  18nMAssay Description:Binding affinity to FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  0.580nMAssay Description:Binding affinity to FLT3 ITD/D835V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to FLT3 ITD/F691L mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  121nMAssay Description:Binding affinity to FLT3 K663Q mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  77nMAssay Description:Binding affinity to FLT3 N841I mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  67nMAssay Description:Binding affinity to FLT3 R834Q mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50629602(CHEMBL5401158)
Affinity DataKd:  121nMAssay Description:Binding affinity to autoinhibited FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed