BDBM50629371 CHEMBL5439097

SMILES CC(C)c1nn(Cc2nnc(o2)-c2ccc(nc2Cl)C(F)(F)F)c(=O)c2cc3sc(Cl)cc3n12

InChI Key InChIKey=LBCNPILPPQLOKG-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50629371   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629371(CHEMBL5439097)
Affinity DataIC50: 320nMAssay Description:Inhibition of NLRP3 inflammasome in PMA-differentiated human THP-1 cells assessed as inhibition of LPS/nigericin-induced IL-1 beta secretion pretreat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629371(CHEMBL5439097)
Affinity DataIC50: 280nMAssay Description:Inhibition of NLRP3 inflammasome in PMA-differentiated human THP-1 cells assessed as inhibition of LPS/nigericin-induced IL-1 beta secretion pretreat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629371(CHEMBL5439097)
Affinity DataIC50: 380nMAssay Description:Inhibition of NLRP3 inflammasome in C57BL/6 mouse BMDM cells assessed as inhibition of LPS/nigericin-induced IL-1 beta secretion pretreated with LPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629371(CHEMBL5439097)
Affinity DataKd:  110nMAssay Description:Binding affinity to human recombinant NLRP3 (1 to 1036 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed