BDBM50629128 CHEMBL5422263::US20250090540, Example I-52

SMILES Cc1ccccc1Nc1ncc(cc1NC(=O)c1cc(F)cc(c1)C(F)(F)F)C(=O)NCc1ccnn1C

InChI Key InChIKey=RNESJMONQIAVQF-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50629128   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Usona Institute

Curated by ChEMBL

LigandBDBM50629128(CHEMBL5422263 | US20250090540, Example I-52)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Inhibition of PIK3CA (unknown origin) using diC8-PIP2 as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Usona Institute

Curated by ChEMBL

LigandBDBM50629128(CHEMBL5422263 | US20250090540, Example I-52)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PIK3CA (unknown origin) expressed in MCF-10A cells incubated for 2 hrs by HTRF methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Usona Institute

Curated by ChEMBL

LigandBDBM50629128(CHEMBL5422263 | US20250090540, Example I-52)Copy SMILESCopy InChI

Affinity DataIC50: 300nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/28/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL