BDBM50628961 CHEMBL5421220

SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)C1(F)CC1)C(C)(C)C)c1ccc(cc1C)-c1scnc1C

InChI Key InChIKey=NBHYPBDUODSQHJ-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50628961   

TargetElongin-C(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50628961(CHEMBL5421220)
Affinity DataKd:  37nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues)/Elongin B/Elogin C (unknown origin) using (FAM)-labeled HIF-1alpha peptide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50628961(CHEMBL5421220)
Affinity DataKd:  25nMAssay Description:Binding affinity to biotinylated VHL/Elongin B/Elongin C (unknown origin) immobilized in SA sensor chip assessed as dissociation constant by SPR anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50628961(CHEMBL5421220)
Affinity DataIC50: 164nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo substrate incubated for 30 mins by tracer based NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50628961(CHEMBL5421220)
Affinity DataIC50: 122nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in permeabilized HEK293 cells using NanoGlo substrate incubated for 30 mins by tracer ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed